Detection, mechanisms, and therapeutic implications of oncometabolites

Trends Endocrinol Metab. 2023 Dec;34(12):849-861. doi: 10.1016/j.tem.2023.08.018. Epub 2023 Sep 20.


Metabolic abnormalities are a hallmark of cancer cells and are essential to tumor progression. Oncometabolites have pleiotropic effects on cancer biology and affect a plethora of processes, from oncogenesis and metabolism to therapeutic resistance. Targeting oncometabolites, therefore, could offer promising therapeutic avenues against tumor growth and resistance to treatments. Recent advances in characterizing the metabolic profiles of cancer cells are shedding light on the underlying mechanisms and associated metabolic networks. This review summarizes the diverse detection methods, molecular mechanisms, and therapeutic targets of oncometabolites, which may lead to targeting oncometabolism for cancer therapy.

Keywords: cancer; mechanism; metabolomics; oncometabolites; target.

Publication types

  • Review

MeSH terms

  • Carcinogenesis
  • Cell Transformation, Neoplastic / metabolism
  • Humans
  • Metabolic Networks and Pathways
  • Metabolome
  • Neoplasms* / metabolism