Sexually differentiated actions of 3-PPP enantiomers on prolactin secretion

Neuropharmacology. 1986 Aug;25(8):951-4. doi: 10.1016/0028-3908(86)90028-6.


The ability of the enantiomers of the atypical dopamine receptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) to counteract gamma-butyrolactone-induced hyperprolactinemia was compared in male and female rats. Following gamma-butyrolactone (GBL) pretreatment serum prolactin concentrations were higher in female than in male rats. In males (-)-3-PPP tended to be somewhat less effective than (+)-3-PPP in decreasing serum prolactin concentrations (levels after (+)-3-PPP and (-)-3-PPP: 21% and 33%, respectively, of levels in GBL-pretreated control(s). In females the (-)-form induced a much weaker response than did the (+)-form (levels after (+)-3-PPP and (-)-3-PPP: 8% and 74%, respectively, of levels in GBL pretreated controls). Parallel experiments replacing GBL by reserpine yielded similar results. Data are discussed in terms of sex differences in responsiveness of pituitary dopamine receptors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / antagonists & inhibitors*
  • Animals
  • Female
  • Furans / antagonists & inhibitors*
  • Male
  • Piperidines / pharmacology*
  • Pituitary Gland, Anterior / drug effects*
  • Pituitary Gland, Anterior / metabolism
  • Prolactin / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects*
  • Sex Factors
  • Stereoisomerism


  • Furans
  • Piperidines
  • Receptors, Dopamine
  • Prolactin
  • preclamol
  • 4-Butyrolactone