A Potential Role of NFIL3 in Atherosclerosis

Guang-Gui Zeng; Jing Zhou; Wan-Li Jiang; Jiang Yu; Gui-Ying Nie; Jing Li; Shi-Qian Zhang; Chao-Ke Tang

doi:10.1016/j.cpcardiol.2023.102096

A Potential Role of NFIL3 in Atherosclerosis

Curr Probl Cardiol. 2024 Jan;49(1 Pt B):102096. doi: 10.1016/j.cpcardiol.2023.102096. Epub 2023 Sep 21.

Authors

Guang-Gui Zeng¹, Jing Zhou², Wan-Li Jiang³, Jiang Yu³, Gui-Ying Nie⁴, Jing Li³, Shi-Qian Zhang³, Chao-Ke Tang⁵

Affiliations

¹ Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; 2020 Grade Excellent Doctor Class of Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.
² Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; School of Pharmaceutical Science, University of South China, Hengyang City, Hunan Province 421001, PR China.
³ Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Departments of Clinical Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China.
⁴ Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; 2019 Grade Excellent Doctor Class of Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.
⁵ Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address: tangchaoke@qq.com.

PMID: 37741601
DOI: 10.1016/j.cpcardiol.2023.102096

Abstract

Nuclear factor interleukin-3 (NFIL3), a proline- and acidic-residue-rich (PAR) bZIP transcription factor, is called the E4 binding protein 4 (E4BP4) as well, which is relevant to regulate the circadian rhythms and the viability of cells. More and more evidence has shown that NFIL3 is associated with different cardiovascular diseases. In recent years, it has been found that NFIL3 has significant functions in the progression of atherosclerosis (AS) via the regulation of inflammatory response, macrophage polarization, some immune cells and lipid metabolism. In this overview, we sum up the function of NFIL3 during the development of AS and offer meaningful views how to treat cardiovascular disease related to AS.

Publication types

Review

MeSH terms

Atherosclerosis*
Basic-Leucine Zipper Transcription Factors / metabolism
Humans
Interleukin-3*

Substances

Interleukin-3
Basic-Leucine Zipper Transcription Factors
NFIL3 protein, human