Obesity in Heart Failure with Reduced Ejection Fraction: Time to Address the Elephant in the Room

Matthew B Amdahl; Varun Sundaram; Yogesh N V Reddy

doi:10.1016/j.ccl.2023.06.010

Obesity in Heart Failure with Reduced Ejection Fraction: Time to Address the Elephant in the Room

Cardiol Clin. 2023 Nov;41(4):537-544. doi: 10.1016/j.ccl.2023.06.010. Epub 2023 Jul 24.

Authors

Matthew B Amdahl¹, Varun Sundaram², Yogesh N V Reddy³

Affiliations

¹ Department of Cardiovascular Diseases, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA.
² Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44106, USA.
³ Department of Cardiovascular Diseases, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA; University Hospitals Medical Center, Cleveland, OH, USA. Electronic address: reddy.yogesh@mayo.edu.

PMID: 37743076
DOI: 10.1016/j.ccl.2023.06.010

Abstract

Obesity has been long recognized as a risk factor for the development of heart failure, but recent evidence suggests obesity is more typically associated with heart failure with preserved ejection fraction as opposed to heart failure with reduced ejection fraction (HFrEF). Nevertheless, numerous studies have found that obesity modulates the presentation and progression of HFrEF and may contribute to the development of HFrEF in some patients. Although obesity has definite negative effects in HFrEF patients, the effects of intentional weight loss in HFrEF patients with obesity have been poorly studied.

Keywords: HFrEF; Heart failure; Obesity; Weight loss.

Publication types

Review

MeSH terms

Heart Failure* / complications
Heart Failure* / epidemiology
Heart Failure* / therapy
Humans
Obesity / complications
Obesity / epidemiology
Risk Factors
Stroke Volume