Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer's disease

Shu Feng; Yongzhen Liu; Yu Zhou; Zhenfeng Shu; Zhuxi Cheng; Charles Brenner; Pinghui Feng

doi:10.3389/fnagi.2023.1245904

Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer's disease

Front Aging Neurosci. 2023 Sep 7:15:1245904. doi: 10.3389/fnagi.2023.1245904. eCollection 2023.

Authors

Shu Feng¹, Yongzhen Liu², Yu Zhou², Zhenfeng Shu², Zhuxi Cheng^{2

3}, Charles Brenner¹, Pinghui Feng^{2

4}

Affiliations

¹ Department of Diabetes and Cancer Metabolism, City of Hope National Medical Center, Duarte, CA, United States.
² Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States.
³ International Department, Beijing Bayi School, Beijing, China.
⁴ Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Los Angeles, CA, United States.

Abstract

Alzheimer's Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human herpesviruses are ubiquitous infectious agents that underpin numerous inflammatory disorders including neurodegenerative diseases. Published studies concerning human herpesviruses in AD imply an active role HSV-1 in the pathogenesis of AD. This review will summarize the current understanding of HSV-1 infection in AD and highlight some barriers to advance this emerging field.

Keywords: Alzheimer’s disease; HSV-1; genetic risk genes; innate immunity; metabolism.

Publication types

Review