The Assessment of TLR1 Gene Polymorphism Association with the Risk of Allergic Rhinitis in the Chinese Han Population from Northern China

Hui Han; Penggang Lian; Haiyuan Chen; Bilal Haider Shamsi; Yonglin Liu; Yongliang Niu

doi:10.2147/JAA.S421939

The Assessment of TLR1 Gene Polymorphism Association with the Risk of Allergic Rhinitis in the Chinese Han Population from Northern China

J Asthma Allergy. 2023 Sep 18:16:979-986. doi: 10.2147/JAA.S421939. eCollection 2023.

Authors

Hui Han¹, Penggang Lian², Haiyuan Chen³, Bilal Haider Shamsi⁴, Yonglin Liu⁴, Yongliang Niu⁵

Affiliations

¹ Clinical Laboratory, Shenmu Hospital, the Affiliated Shenmu Hospital of Northwest University, Shenmu, 719300, People's Republic of China.
² Otorhinolaryngologic Department, Shenmu Hospital, the Affiliated Shenmu Hospital of Northwest University, Shenmu, 719300, People's Republic of China.
³ Information Department, Shenmu Hospital, the Affiliated Shenmu Hospital of Northwest University, Shenmu, 719300, People's Republic of China.
⁴ Department of Science and Education, Shenmu Hospital, the Affiliated Shenmu Hospital of Northwest University, Shenmu, 719300, People's Republic of China.
⁵ Department of Respiratory and Critical Care Medicine, Shenmu Hospital, the Affiliated Shenmu Hospital of Northwest University, Shenmu, 719300, People's Republic of China.

Abstract

Background: Environmental factors and genetic predisposition can influence the occurrence and development of AR. Toll-like receptor 1 (TLR1) belongs to the TLR receptor family, which plays a fundamental role in the activation of innate immunity. This study aimed to explore the association between TLR1 genetic loci and AR susceptibility in the Han Chinese from northern China.

Methods: Genotyping of three SNPs in the TLR1 has proceeded using the Agena MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the correlation between candidate SNPs and AR susceptibility. Using FPRP (false-positive report probability analysis) to detect whether the positive results are noteworthy findings. The SNP-SNP interactions were detected by multifactor dimensionality reduction (MDR).

Results: TLR1-rs72493538 (Allele "G": OR=0.77, p = 0.034) and -rs76600635 (Allele "G": OR=0.75, p = 0.024) were associated with reducing the risk of AR among Han Chinese in northern China. In addition, we found evidence that TLR1-rs72493538 (males, participants with aging > 43 years, or coming from the wind-blown sand region) and -rs76600635 (males, participants with BMI ≤ 24 kg/m², or coming from the wind-blown sand region) were associated with AR risk in stratified analyses. FPRP showed that all positive results are noteworthy findings. MDR analysis showed that a two-loci genetic model composed of rs72493538 and rs76600635 can be chosen as the best genetic model to predict the risk of AR.

Conclusion: TLR1-rs72493538 and -rs76600635 have a close association with reducing the risk of AR.

Keywords: TLR1; allergic rhinitis; case-control study; susceptibility.

Grants and funding

This study was supported by Natural Science Foundation of Shaanxi Province (2021SF-075), Science and Technology Plan Project of Yulin City (YF-2020-191) and Shenmu Municipal Government Scientific Research Project (2019) No.5.