The potential role of combined shear wave elastography and superb microvascular imaging for early prediction the pathological response to neoadjuvant chemotherapy in breast cancer

Jiaojiao Qi; Chenyu Wang; Yongxin Ma; Jiaxing Wang; Guangfei Yang; Yating Wu; Haiyan Wang; Chengrong Mi

doi:10.3389/fonc.2023.1176141

The potential role of combined shear wave elastography and superb microvascular imaging for early prediction the pathological response to neoadjuvant chemotherapy in breast cancer

Front Oncol. 2023 Sep 8:13:1176141. doi: 10.3389/fonc.2023.1176141. eCollection 2023.

Authors

Jiaojiao Qi¹, Chenyu Wang², Yongxin Ma², Jiaxing Wang¹, Guangfei Yang³, Yating Wu³, Haiyan Wang¹, Chengrong Mi³

Affiliations

¹ Department of Obstetrics and Gynecology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
² Ningxia Medical University, Yinchuan, Ningxia, China.
³ Department of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.

Abstract

Objectives: The potential role of shear wave elastography (SWE) and superb microvascular imaging (SMI) for early assessment of treatment response to neoadjuvant chemotherapy (NAC) in breast cancer remains unexplored. This study aimed to identify potential factors associated with the pathological response to NAC using these advanced ultrasound techniques.

Methods: Between August 2021 and October 2022, 68 patients with breast cancer undergoing NAC were recruited. Patients underwent conventional ultrasonography, SMI, and SWE examinations at baseline and post-2^nd cycle of NAC. Maximum tumor diameter (Dmax), maximum elastic value (Emax), peak systolic velocity (PSV), and resistance index (RI) at baseline and the rate of change of these parameters post-2^nd cycle were recorded. After chemotherapy, all patients underwent surgery. Using the Miller-Payne's grade, patients were categorized into response (grades 3, 4, or 5) and non-response (grades 1 or 2) group. Parameters were compared using t-tests at baseline and post-2^nd cycle. Binary logistic regression analysis was used to identify variables and their odds ratios (ORs) related to responses and a prediction model was established. ROC curves were drawn to analyze the efficacy of each parameter and their combined model for early NAC response prediction.

Results: Among the 68 patients, 15(22.06%) were categorized into the non-response group, whereas 53(77.94%) were categorized into the response group. At baseline, no significant differences were observed between the two groups (p>0.05). Post-2^nd cycle of NAC, rates of change of Emax, PSV and RI (ΔEmax, ΔPSV and ΔRI) were higher in responders than non-responders (p<0.05). Binary logistic regression analysis revealed that ΔEmax (OR 0.797 95% CI, 0.683-0.929), ΔPSV (OR 0.926, 95%CI, 0.860-0.998), and ΔRI (OR 0.841, 95%CI, 0.736-0.960) were independently associated with the pathological response of breast cancer after NAC. The combined prediction model exhibited higher accuracy in the early evaluation of the response to NAC (AUC 0.945, 95%CI, 0.873-1.000).

Conclusion: SWE and SMI techniques enable early identification of tumor characteristics associated with the pathological response to NAC and may be potentially indicative of an effective response. These factors may eventually be used for the early assessment of NAC treatment for clinical management.

Keywords: breast cancer; neoadjuvant chemotherapy (NAC); pathological response; shear wave elastography (SWE); superb microvascular imaging (SMI).

Grants and funding

This study was funded by the National Natural Science Foundations of China (grants 81960317, 82260351 and 8226070416); Key R&D Program of Ningxia Hui Autonomous Region (No: 2022BEG03100).