A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

Microbiol Resour Announc. 2023 Oct 19;12(10):e0050723. doi: 10.1128/MRA.00507-23. Epub 2023 Sep 25.


Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

Keywords: Clostridiodes; Clostridium difficile; X-ray; pipeline; protein structure-function; structural genomics.