A double-blind trial of loperamide in the treatment of chronic diarrhoea

S Afr Med J. 1979 Mar 24;55(13):502-3.


A new antidiarrhoeal compound, loperamide (Imodium; (Janssen) Ethnor) has been evaluated in the treatment of patients with chronic nonspecific diarrhoea. In a double-blind trial its effect was compared with that of a placebo. The results of this trial indicate that loperamide is an effective antidiarrhoeal compound.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Chronic Disease
  • Clinical Trials as Topic
  • Diarrhea / drug therapy*
  • Double-Blind Method
  • Female
  • Humans
  • Loperamide / therapeutic use*
  • Male
  • Middle Aged
  • Piperidines / therapeutic use*


  • Piperidines
  • Loperamide