Motilin in chronic idiopathic constipation

Scand J Gastroenterol. 1986 Oct;21(8):914-8. doi: 10.3109/00365528608996395.


The plasma motilin levels were studied in seven patients with severe long-standing idiopathic constipation before and after a fat-rich test meal. The results were compared with those of a control group consisting of 10 apparently healthy persons with normal bowel function. The constipated patients had reduced basal motilin levels and a reduced motilin release after the test meal. Motilin is known to stimulate intestinal motility by inducing interdigestive descending contractions in the stomach and small intestine. A defective motilin release may therefore play a part in the pathogenesis of idiopathic constipation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Constipation / blood*
  • Constipation / etiology
  • Dietary Fats / administration & dosage
  • Female
  • Food
  • Gastrointestinal Motility
  • Humans
  • Middle Aged
  • Motilin / blood*
  • Radioimmunoassay


  • Dietary Fats
  • Motilin