Nanomedicine as a potential novel therapeutic approach against the dengue virus

Nanomedicine (Lond). 2023 Sep;18(22):1567-1584. doi: 10.2217/nnm-2022-0217. Epub 2023 Sep 27.


Dengue is an arbovirus infection which is transmitted by Aedes mosquitoes. Its prompt detection and effective treatment is a global health challenge. Various nanoparticle-based vaccines have been formulated to present immunogen (antigens) to instigate an immune response or prevent virus spread, but no specific treatment has been devised. This review explores the role of nanomedicine-based therapeutic agents against dengue virus, taking into consideration the applicable dengue virus assays that are sensitive, specific, have a short turnaround time and are inexpensive. Various kinds of metallic, polymeric and lipid nanoparticles with safe and effective profiles present an alternative strategy that could provide a better remedy for eradicating the dengue virus.

Keywords: arbovirus; calcium phosphate nanoparticle vaccine; dengue infection; dengue virus; drug delivery; nanomedicine; nanoparticle-based vaccines; nanotherapeutics; nanovaccine; therapeutic approach.

Publication types

  • Review

MeSH terms

  • Aedes*
  • Animals
  • Dengue Virus* / physiology
  • Dengue* / drug therapy
  • Dengue* / prevention & control
  • Nanomedicine