Pediatric and Hereditary Mastocytosis

Immunol Allergy Clin North Am. 2023 Nov;43(4):665-679. doi: 10.1016/j.iac.2023.04.001. Epub 2023 May 19.


To a large extent, the clinical picture of pediatric mastocytosis depends on the age at which it is diagnosed. A neonate with diffuse cutaneous mastocytosis may frequently present in a severe state requiring treatment. Toddlers may require long-term anti-mediator therapy, and this may lead to concerns such as organizing preschool education due to the need for epinephrine injections. A teenager may have to face cutaneous disease persistence or a diagnosis of systemic mastocytosis. Further studies are needed to refine the available treatment options and prognosis for different age groups.

Keywords: Children; Mastocytosis; Neonates; Teenagers; Toddlers.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Humans
  • Infant, Newborn
  • Mastocytosis* / diagnosis
  • Mastocytosis* / genetics
  • Mastocytosis* / therapy
  • Mastocytosis, Cutaneous* / diagnosis
  • Mastocytosis, Cutaneous* / genetics
  • Mastocytosis, Cutaneous* / therapy
  • Mastocytosis, Systemic*
  • Prognosis