The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications

Cells. 2023 Sep 19;12(18):2312. doi: 10.3390/cells12182312.

Abstract

Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, discuss chemical inhibitors of this process, and discuss potential clinical applications of the endocytosis inhibitors.

Keywords: cell-penetrating peptides; clathrin-independent endocytosis; clathrin-mediated endocytosis; inhibitors of endocytosis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Endocytosis* / drug effects