The Effectiveness of Shared Decision-making for Diabetes Prevention: 24- and 36-Month Results From the Prediabetes Informed Decision and Education (PRIDE) Trial

Diabetes Care. 2023 Dec 1;46(12):2218-2222. doi: 10.2337/dc23-0829.


Objective: We conducted a cluster-randomized, shared decision-making (SDM) trial offering lifestyle change, metformin, or both options, to adults at risk for diabetes in a primary care network (n = 20 practices).

Research design and methods: We used propensity score matching to identify control patients and used electronic health record data to compare weight loss at 24 and 36 months of follow-up and diabetes incidence at 36 months of follow-up.

Results: In adjusted post hoc analyses, SDM participants (n = 489) maintained modestly greater 24-month weight loss of -3.1 lb and 36-month weight loss of -2.7 lb versus controls (n = 1,430, both comparisons P < 0.001). SDM participants who chose both lifestyle change and metformin sustained weight loss at 36 months of -4.1 lb (P < 0.001 vs. controls). We found no differences in incident diabetes (15% of SDM participants, 14% of control participants; P = 0.64).

Conclusions: This is one of the first studies to demonstrate weight loss maintenance up to 36 months after diabetes prevention SDM.

MeSH terms

  • Adult
  • Decision Making
  • Decision Making, Shared
  • Humans
  • Life Style
  • Metformin* / therapeutic use
  • Patient Participation
  • Prediabetic State* / drug therapy
  • Weight Loss


  • Metformin