Representations of tactile object location in the retrosplenial cortex

Abstract

How animals use tactile sensation to detect important objects and remember their location in a world-based coordinate system is unclear. Here, we hypothesized that the retrosplenial cortex (RSC), a key network for contextual memory and spatial navigation, represents the location of objects based on tactile sensation. We studied mice palpating objects with their whiskers while navigating in a tactile virtual reality in darkness. Using two-photon Ca²⁺ imaging, we discovered that a population of neurons in the agranular RSC signal the location of objects. Responses to objects do not simply reflect the sensory stimulus. Instead, they are highly position, task, and context dependent and often predict the upcoming object before it is within reach. In addition, a large fraction of neurons encoding object location maintain a memory trace of the object's location. These data show that the RSC encodes the location and arrangement of tactile objects in a spatial reference frame.

Keywords: contextual memory; object location; place cells; retrosplenial cortex; spatial landmarks; spatial navigation; tactile sensation; two-photon microscopy; virtual reality; whiskers.