Molecular mechanisms of 1,2-dichloroethane-induced neurotoxicity

Toxicol Res. 2023 Jul 13;39(4):565-574. doi: 10.1007/s43188-023-00197-x. eCollection 2023 Oct.


The production of industrial solvents and adhesives often utilizes 1,2-dichloroethane (1,2-DCE), a highly toxic halogenated hydrocarbon compound. Occupational 1,2-DCE poisoning occurs frequently and is a public health concern. Exposure to 1,2-DCE can damage the brain, liver, and kidneys. The main and most severe damage caused by exposure to 1,2-DCE is to the nervous system, especially the central nervous system. Current research on 1,2-DCE mainly focuses on the mechanism of brain edema. Several possible mechanisms of 1,2-DCE neurotoxicity have been proposed, including oxidative stress, calcium overload, blood-brain barrier damage, and neurotransmitter changes. This article reviews the research progress on 1,2-DCE neurotoxicity and the mechanism behind it to provide a scientific basis for the prevention and treatment of 1,2-DCE poisoning.

Keywords: 1,2-dichloroethane; Neurotoxicity; Occupational poisoning; Toxic brain edema.

Publication types

  • Review