CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells

Biochem Biophys Res Commun. 1986 Nov 14;140(3):1073-8. doi: 10.1016/0006-291x(86)90744-8.

Abstract

Walker tumour cells were shown to be uniquely sensitive to CB 1954 when compared with other cells in vitro. CB 1954 forms DNA-DNA interstrand crosslinks in a time-dependent manner in Walker tumour but not Chinese hamster cells. The absence of interstrand crosslinks in hamster cells was not due to a lack of uptake of drug but rather to a failure to convert (probably by bioreduction) CB 1954 to the required reactive difunctional intermediate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Aziridines / metabolism
  • Aziridines / pharmacology*
  • Azirines / pharmacology*
  • Carcinoma 256, Walker / metabolism*
  • Cell Survival / drug effects
  • Cricetinae
  • Cricetulus
  • Cross-Linking Reagents*
  • DNA, Neoplasm / drug effects*
  • In Vitro Techniques
  • Rats

Substances

  • Antineoplastic Agents
  • Aziridines
  • Azirines
  • Cross-Linking Reagents
  • DNA, Neoplasm
  • tretazicar