Rational design of EDTA-incorporated nanoflowers as novel and effective endodontic disinfection against biofilms

Odontology. 2024 Apr;112(2):444-452. doi: 10.1007/s10266-023-00857-2. Epub 2023 Oct 3.

Abstract

The ethylenediaminetetradiacetic acid (EDTA) is one of the most commonly used irrigation solutions. Although EDTA has a very low antimicrobial property, it is used to remove inorganic part of smear layer in areas of root canal system. Herein, we developed EDTA-incorporated nanoflowers (EDTA NFs), for the first time, as novel and effective irrigation solution with quite high antimicrobial property to provide complete disinfection in root canal system. We both systematically elucidated the formation of the EDTA NFs with various techniques, and their catalytic and antimicrobial activities in the presence of hydrogen peroxide (H2O2) were documented through intrinsic EDTA property and peroxidase-like activities.

Keywords: EDTA nanoflowers; Biofilms; Catalytic activity; Endodontic disinfection.

MeSH terms

  • Anti-Infective Agents*
  • Biofilms
  • Dental Pulp Cavity
  • Disinfection / methods
  • Edetic Acid / pharmacology
  • Humans
  • Hydrogen Peroxide / pharmacology
  • Root Canal Irrigants / pharmacology
  • Root Canal Preparation / methods
  • Smear Layer*
  • Sodium Hypochlorite

Substances

  • Edetic Acid
  • Hydrogen Peroxide
  • Anti-Infective Agents
  • Root Canal Irrigants
  • Sodium Hypochlorite