N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase

Biochim Biophys Acta. 1986 Nov 28;889(2):236-9. doi: 10.1016/0167-4889(86)90109-6.

Abstract

N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide (SC-9) activated Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). SC-9 acted as a substitute for phosphatidylserine, which is one of the endogenous factors in activating protein kinase C. SC-9 was also effective in regulating the physiological functions at the whole-cell level. For example, SC-9 stimulated hexose transport activity in mouse fibroblasts, a protein kinase C-regulated cellular function. Thus, SC-9 may be useful to study the molecular basis of the regulation of protein kinase C activity, and the biological significance of this enzyme.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-O-Methylglucose
  • Animals
  • Enzyme Activation
  • Kinetics
  • Methylglucosides / metabolism
  • Mice
  • Monosaccharide Transport Proteins / metabolism
  • Phosphatidylserines / pharmacology
  • Protein Kinase C / metabolism*
  • Sulfonamides / pharmacology*

Substances

  • Methylglucosides
  • Monosaccharide Transport Proteins
  • Phosphatidylserines
  • Sulfonamides
  • N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide
  • 3-O-Methylglucose
  • Protein Kinase C