Indications for surgical replacement of the mitral valve. With particular reference to common and uncommon causes of mitral regurgitation

Am J Cardiol. 1979 Jul;44(1):148-57. doi: 10.1016/0002-9149(79)90264-9.


Mitral valve replacement is considered when there is severe mitral stenosis, severe mitral insufficiency or a combination of the two. Ordinarily, surgical replacement is considered only for patients who are in functional classes III or IV and do not respond to medical management. Patients with symptomatic mitral stenosis should be treated with mitral commissurotomy whenever possible. Patients selected for commissurotomy should have a pliable valve, no other major valve dysfunction, sinus rhythm, no systemic embolism and good left ventricular function. Early operation is not ordinarily required. Mitral insufficiency may require mitral valve replacement in six rather common settings: rheumatic disease, rupture of mitral chordae tendineae, postinfarction rupture of a papillary muscle, intractable infective endocarditis, floppy mitral valve and malfunction of a prosthetic valve. Rupture of mitral chordae tendineae can usually be recognized from the history, physical examination, echocardiogram and angiocardiogram. Severe left ventricular papillary muscle dysfunction is usually due to cardiac infarction, and occurs within the first 9 days of infarction. When only a papillary muscle tip is ruptured the patient may survive long enough for a mitral valve replacement. In infective endocarditis, operation is more often needed because of congestive heart failure than because of refractory infection. Evidence of mitral stenosis or insufficiency in a patient with a previously implanted prosthetic valve usually indicates an urgent need for study and early operation. Uncommon causes of mitral incompetence that may require valve replacement are endocardial fibroelastosis, Marfan's syndrome, calcified mitral anulus, osteogenesis imperfecta, methysergide-induced heart disease and carcinoid heart disease.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Calcinosis / complications
  • Calcinosis / surgery
  • Carcinoid Heart Disease / complications
  • Carcinoid Heart Disease / surgery
  • Cardiomyopathies / chemically induced
  • Cardiomyopathies / surgery
  • Cardiomyopathy, Hypertrophic / surgery
  • Child
  • Chordae Tendineae
  • Echocardiography
  • Endocardial Fibroelastosis / complications
  • Endocardial Fibroelastosis / surgery
  • Endocarditis, Bacterial / complications
  • Endocarditis, Bacterial / surgery
  • Female
  • Heart Rupture / complications
  • Heart Rupture / surgery
  • Heart Valve Prosthesis* / adverse effects
  • Heart Valve Prosthesis* / mortality
  • Humans
  • Male
  • Marfan Syndrome / complications
  • Methysergide / adverse effects
  • Methysergide / therapeutic use
  • Middle Aged
  • Mitral Valve / abnormalities
  • Mitral Valve Insufficiency / etiology
  • Mitral Valve Insufficiency / mortality
  • Mitral Valve Insufficiency / surgery*
  • Mitral Valve Stenosis / congenital
  • Mitral Valve Stenosis / mortality
  • Mitral Valve Stenosis / surgery*
  • Osteogenesis Imperfecta / complications
  • Rheumatic Heart Disease / complications
  • Rheumatic Heart Disease / surgery
  • Rupture, Spontaneous


  • Methysergide