Familial Mediterranean fever and microRNAs

Int J Immunogenet. 2023 Dec;50(6):273-280. doi: 10.1111/iji.12640. Epub 2023 Oct 4.

Abstract

Familial Mediterranean fever (FMF) is an inherited disorder caused by the gain of function mutations in MEFV (MEditerranean FeVer) gene loci. FMF affects more than 100,000 people worldwide and generally seen in the eastern Mediterranean region and causes the lifelong diseases which have a significant effect on the patient's life quality and health systems. The identification of low penetrant or heterozygous MEFV gene mutations in clinically diagnosed FMF patients was considered that epigenetic or environmental factors may display a role in FMF pathogenesis. Epigenetics might be defined as heritable changes that affect gene expression without any changes in the genome. MicroRNAs (miRNAs) are the main group of small noncoding RNAs, and an important element of epigenetic mechanisms and their discoveries revolutionized our knowledge about biological processes, such as malignant, infectious and autoimmune mechanisms, and contributed to the development of the epigenetic areas. In this review, the studies focusing on the roles of miRNAs in FMF pathogenesis in the last decades were examined and the importance of miRNAs as therapeutic agents which are promising for diagnosis and treatment was discussed.

Keywords: AAA; FMF; epigenetics; epigenetik; genetics; genetik; miRNA.

Publication types

  • Review

MeSH terms

  • Familial Mediterranean Fever* / genetics
  • Heterozygote
  • Humans
  • MicroRNAs*
  • Mutation
  • Pyrin / genetics

Substances

  • MicroRNAs
  • MEFV protein, human
  • Pyrin