Mesenchymal stromal cells as conductors of adipose tissue remodeling

Genes Dev. 2023 Sep 1;37(17-18):781-800. doi: 10.1101/gad.351069.123. Epub 2023 Oct 5.


Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response to changes in physiological and environmental conditions. Here, we describe recent advances in our understanding of how functionally distinct tissue-resident mesenchymal stromal cell subpopulations orchestrate several aspects of physiological and pathophysiological adipose tissue remodeling, with a particular focus on the adaptations that occur in response to changes in energy surplus and environmental temperature. The study of adipose tissue remodeling provides a vehicle to understand the functional diversity of stromal cells and offers a lens through which several generalizable aspects of tissue reorganization can be readily observed.

Keywords: adipogenesis; adipose tissue; fibrosis; inflammation; mesenchymal stromal cells; obesity; white adipocyte.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipogenesis*
  • Adipose Tissue
  • Humans
  • Mesenchymal Stem Cells*
  • Obesity
  • Stromal Cells