It must be ensured that dermatologists practice enhanced antibiotic stewardship to combat antimicrobial resistance and negative consequences of microbiome dysbiosis. In order to help achieve this, we have developed a mnemonic ENLIGHTEN to help healthcare providers and patients understand sarecycline’s features.J Drugs Dermatol. 2023;22(10):1061 doi:10.36849/JDD.7437R1.