Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene

Endocrinology. 1986 Dec;119(6):2864-6. doi: 10.1210/endo-119-6-2864.


When bovine parathyroid cells in culture are exposed to the active vitamin D metabolite 1,25(OH)2D3, a significant decrease in the steady-state levels of pre-proparathyroid hormone (pre-proPTH) mRNA occurs. The possibility that the fall in specific mRNA is due to a decrease in rate of transcription of the PTH gene was examined in this study. In the presence of 1,25(OH)2D3, there was a rapid and steady decline in PTH gene transcription rate which fell to a minimum of 10-15% of control at 24 h. The effect was observed at physiological levels (10(-11)M) and was also fully reversible.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcitriol / pharmacology*
  • Cattle
  • Gene Expression Regulation / drug effects
  • In Vitro Techniques
  • Parathyroid Glands / physiology*
  • Parathyroid Hormone / genetics*
  • Protein Precursors / genetics*
  • RNA, Messenger / metabolism
  • Transcription, Genetic / drug effects


  • Parathyroid Hormone
  • Protein Precursors
  • RNA, Messenger
  • preproparathormone
  • Calcitriol