Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold

Commun Biol. 2023 Oct 7;6(1):1017. doi: 10.1038/s42003-023-05383-z.


Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering "living" heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and "morphodynamism".

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Heart Valve Prosthesis*
  • Heart Valves
  • Quality of Life
  • Tissue Engineering*
  • Tissue Scaffolds