Clinical characteristics and management outcomes of acute retinal necrosis

Sci Rep. 2023 Oct 7;13(1):16927. doi: 10.1038/s41598-023-44310-4.


This study investigates patient's clinical characteristics and management outcomes of PCR-positive Acute Retinal Necrosis (ARN). The patient's clinical characteristics of the disease, and therapeutic approaches were assessed. Data from the medical records of 40 eyes of 40 patients were analyzed. The mean ± standard deviation (SD) of the age of the patients was 47.8 ± 14.1 years (16-84 years old). The median follow-up time was 160 days, with a range of 120-370 days. The mean ± SD of patients' primary and final BCVA was 1.24 ± 0.78 and 1.08 ± 0.86 LogMAR, respectively. The final BCVA increased significantly after the treatment in the last follow-up period in patients who did not undergo PPV (p = 0.029). Although, vision changes were not statistically significant in patients who underwent PPV (p = 0.549). 75% of our patients had a positive aqueous PCR for VZV, and the second most common causative agents were CMV and HSV (10% for each). Besides, rhegmatogenous retinal detachment (RRD) occurred in 25% of our patients. Our analysis showed that the presenting visual acuity and RRD occurrence are the significant prognostic factors for final blindness in ARN.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Eye
  • Humans
  • Middle Aged
  • Retinal Detachment* / surgery
  • Retinal Necrosis Syndrome, Acute* / diagnosis
  • Retinal Necrosis Syndrome, Acute* / drug therapy
  • Retrospective Studies
  • Scleral Buckling / adverse effects
  • Vitrectomy / adverse effects
  • Young Adult