Nerve and muscle regeneration after axonal division in rats treated with isaxonine phosphate (isopropylamino-2-pyrimidine phosphate)

Eur Surg Res. 1986;18(6):383-9. doi: 10.1159/000128551.


Isaxonine phosphate (isopropylamino-2-pyrimidine phosphate), a neurotrophic agent, was tested on Schwann cell and muscle metabolism as evidenced by radiophosphate uptake in the inorganic phosphate and organic-bound acid-soluble phosphate fractions. It had no demonstrable effect either on sciatic nerve Schwann cells above and below an experimental crush or on the corresponding gastrocnemius and soleus muscles in their denervated and reinnervated state (7th to 28th postoperative day). It also failed to influence the end results (150th postoperative day) at nerve and muscle level after surgical division of the nerve and repair by either microsuture or fibrinogen adhesive.

MeSH terms

  • Animals
  • Axons / physiology*
  • Male
  • Muscles / drug effects
  • Muscles / physiology*
  • Nerve Degeneration / drug effects
  • Nerve Regeneration / drug effects*
  • Phosphates / metabolism
  • Pyrimidines / pharmacology*
  • Rats
  • Regeneration / drug effects*
  • Sciatic Nerve / physiology*
  • Sciatic Nerve / surgery


  • Phosphates
  • Pyrimidines
  • isaxonine