A retina-derived stimulator(s) of retinal pigment epithelial cell and astrocyte proliferation

Exp Eye Res. 1986 Sep;43(3):449-57. doi: 10.1016/s0014-4835(86)80080-x.


Retinal detachments are frequently accompanied by retinal pigment epithelial cell and glial cell proliferation. This may be important in the pathogenesis of proliferative vitreoretinopathy and may also play a role in the failure of some eyes to regain visual function despite anatomically successful retinal reattachment surgery. In this study, we demonstrate that a retina-derived substance or substances stimulates the proliferation of retinal pigment epithelial cells (250% above control) and astrocytes (150% above control) in vitro. The stimulation of proliferation occurs in the absence of serum, but is accentuated by serum. There is some degree of target-cell specificity as there is no stimulation of smooth-muscle-cell proliferation. Morphologic changes induced in the proliferating cell types as well as preliminary characterization suggest that one or more of the previously described eye-derived growth factors may be involved.

MeSH terms

  • Animals
  • Astrocytes / cytology
  • Astrocytes / drug effects*
  • Cattle
  • Cell Division / drug effects
  • Cells, Cultured
  • Fibroblast Growth Factors
  • Growth Substances / analysis
  • Growth Substances / pharmacology*
  • Pigment Epithelium of Eye / cytology
  • Pigment Epithelium of Eye / drug effects*
  • Retina / analysis


  • Growth Substances
  • eye-derived growth factor
  • Fibroblast Growth Factors