Chronic Spontaneous Urticaria Following COVID-19 Vaccination: A Case Report and Discussion on Allergic Reactions and Vaccine Safety

Jesus Ivan Martinez-Ortega; Felipe de Jesus Perez Hernandez

doi:10.7759/cureus.44860

Chronic Spontaneous Urticaria Following COVID-19 Vaccination: A Case Report and Discussion on Allergic Reactions and Vaccine Safety

Cureus. 2023 Sep 7;15(9):e44860. doi: 10.7759/cureus.44860. eCollection 2023 Sep.

Authors

Jesus Ivan Martinez-Ortega¹, Felipe de Jesus Perez Hernandez²

Affiliations

¹ Department of Dermatology, Dermatological Institute of Jalisco "Dr. Jose Barba Rubio", Zapopan, MEX.
² Department of Internal Medicine, Pensiones Medical Center, Merida, MEX.

Abstract

This case report examines a rare occurrence of chronic spontaneous urticaria (CSU) following the administration of the CoronaVac vaccine for COVID-19. The patient developed persistent urticarial lesions that appeared and disappeared over an extended period after receiving the vaccine. The diagnosis of CSU was supported by histopathological examination and the close temporal correlation between symptom onset and vaccination. The discussion focuses on the immune mechanisms involved in CSU, the potential triggers of allergic reactions to COVID-19 vaccines, and the importance of further research to identify specific allergenic components. This case underscores the need for vigilance in monitoring and reporting adverse events related to COVID-19 vaccination to ensure vaccine safety and optimize public health strategies.

Keywords: allergic reaction; chronic spontaneous urticaria; covid-19 vaccine; sars-cov-2; vaccine safety.

Publication types

Case Reports