Acellular Collagen Matrix Patch Augmentation of Arthroscopic Rotator Cuff Repair Reduces Re-Tear Rates: A Meta-analysis of Randomized Control Trials

Arthroscopy. 2024 Mar;40(3):941-946. doi: 10.1016/j.arthro.2023.09.025. Epub 2023 Oct 8.

Abstract

Purpose: To perform a meta-analysis of randomized controlled trials (RCTs) to compare the outcomes of arthroscopic rotator cuff repair (ARCR) with and without acellular collagen matrix patch (ACMP) augmentation.

Methods: A literature search of 3 databases was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. RCTs comparing ACMP augmentation and a control for ARCR were included. Clinical outcomes were compared using Revman, and a P value < .05 was considered to be statistically significant.

Results: Five RCTs with 307 patients were included. Overall, 11% of patients treated with ACMP augmentation and 34% of patients in the control group had a re-tear (P = .0006). The mean Constant score was 90.1 with ACMP augmentation, and 87.3 in controls (P = .02). Additionally, there was a significant higher American Shoulder and Elbow Surgeons score with ACMP augmentation (87.7 vs 82.1, P = .01).

Conclusions: The RCTs in the literature support the use of ACMP augment as a modality to reduce re-tear rates and improve outcomes after ARCR.

Level of evidence: Level II, Meta-Analysis of Level II Studies meta-analysis of Level II studies.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopyridines*
  • Collagen / therapeutic use
  • Humans
  • Lacerations*
  • Randomized Controlled Trials as Topic
  • Rotator Cuff / surgery
  • Rotator Cuff Injuries* / surgery
  • Rupture
  • Treatment Outcome

Substances

  • 2-amino-3-cyano-6-methyl-5-(4-pyridyl)pyridine
  • Aminopyridines
  • Collagen