Triacsins, new inhibitors of acyl-CoA synthetase produced by Streptomyces sp

J Antibiot (Tokyo). 1986 Sep;39(9):1211-8. doi: 10.7164/antibiotics.39.1211.


Triacsins A and B, new inhibitors of acyl-CoA synthetase, were isolated from the cultured broth of Streptomyces sp. strain SK-1894. The structurally related compounds WS-1228 A and B, known as hypotensive vasodilators, were also found to inhibit acyl-CoA synthetase. The four compounds have in common a N-hydroxytriazene moiety in their structures. The IC50 values for triacsin A and WS-1228 A were 5.5 and 3.6 micrograms/ml, respectively.

MeSH terms

  • Chemical Phenomena
  • Chemistry
  • Coenzyme A Ligases / antagonists & inhibitors*
  • Fermentation
  • Spectrum Analysis
  • Streptomyces / classification
  • Streptomyces / metabolism*
  • Triazenes / isolation & purification*
  • Triazenes / pharmacology


  • Triazenes
  • triacsin A
  • triacsin B
  • triacsin C
  • triacsin D
  • Coenzyme A Ligases