Laryngeal verrucous cell carcinoma

Curr Opin Otolaryngol Head Neck Surg. 2024 Apr 1;32(2):118-124. doi: 10.1097/MOO.0000000000000910. Epub 2023 Oct 10.


Purpose of review: To summarize the recent literature on epidemiology, clinical findings, treatment, and survival of laryngeal verrucous cell carcinoma (LVC).

Recent findings: Epidemiological studies report that LVC accounts for 1-3% of all laryngeal cancers. The incidence is decreasing, while most patients are male individuals and smokers. LVC are commonly detected in early stages because they are more frequently located in the glottic region. Tobacco, alcohol overuse, and, possibly, human papilloma virus are the main contributing factors. Recent studies confirm that surgery is the primary therapeutic approach with better prognosis when compared with other treatment modalities. Surgery alone is associated with 86.8% disease-free and 80.3% overall survival rates, while metastases are anecdotal.

Summary: LVC presents different clinical, pathological, and survival outcomes when compared with the classic laryngeal squamous cell carcinoma. Biopsies need often to be repeated before getting the most appropriate diagnosis; this supports the need of large-sample biopsy during the tumor diagnosis and staging. The glottic location of most LVC leads to detection of this lesion in its early stages, with ensuing better survival and outcomes after surgery compared with the classic form of squamous cell carcinoma. Future studies are needed to understand the biology of LVC and its related better prognostic outcomes when compared to other laryngeal malignancies.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell* / pathology
  • Female
  • Head and Neck Neoplasms* / pathology
  • Humans
  • Laryngeal Neoplasms* / diagnosis
  • Laryngeal Neoplasms* / epidemiology
  • Laryngeal Neoplasms* / surgery
  • Larynx*
  • Male
  • Neoplasm Staging
  • Prognosis
  • Squamous Cell Carcinoma of Head and Neck / pathology