Treatment of neonatal hyperthyroidism due to Graves' disease with sodium ipodate

J Clin Endocrinol Metab. 1987 Jan;64(1):119-23. doi: 10.1210/jcem-64-1-119.

Abstract

We describe the effect of administration of repeated doses of sodium ipodate in a newborn infant with hyperthyroidism due to transient Graves' disease. Pretreatment (day 3) serum T4 and T3 concentrations were 49 micrograms/dl and 590 ng/dl, respectively. With 24 h after the first dose of ipodate, serum T3 fell by 40%, and it subsequently ranged from 209-278 ng/dl throughout the 39-day ipodate treatment period. Serum T4 also decreased after ipodate administration to 69% and 41% of the pretreatment value after 72 h and 7 days of treatment, respectively; values thereafter during treatment ranged from 19-22 micrograms/dl. These plateau values are in the upper range of normal for the neonatal period. Rapid clinical improvement occurred as the hyperiodothyroninemia abated. Serum rT3 concentrations increased from 468-672 ng/dl to greater than 1400 ng/dl 24 h after each ipodate dose. Thyroid-stimulating immunoglobulin was present in maternal and cord sera, and the half-life of serum thyroid-stimulating immunoglobulin in the infant was approximately 12 days. Antithyroglobulin and antimicrosomal antibodies were present in the infant at 10 days of age, and the titers decreased progressively thereafter; the half-life for the antimicrosomal antibody titer was 3 weeks. The data suggest that sodium ipodate can be useful for treatment of neonatal hyperthyroidism due to Graves' disease.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies / analysis
  • Female
  • Graves Disease / complications*
  • Humans
  • Hyperthyroidism / blood
  • Hyperthyroidism / drug therapy*
  • Hyperthyroidism / etiology
  • Infant, Newborn
  • Ipodate / therapeutic use*
  • Thyroid Gland / immunology
  • Thyrotropin / blood
  • Thyroxine / blood
  • Triiodothyronine / blood
  • Triiodothyronine, Reverse / blood

Substances

  • Antibodies
  • Triiodothyronine
  • Triiodothyronine, Reverse
  • Thyrotropin
  • Ipodate
  • Thyroxine