Maintaining a healthy balance: How endothelial AHR signaling helps regulate tissue homeostasis and protection

Rachel P Tat; Christopher M Robinson

doi:10.1016/j.chom.2023.09.008

Maintaining a healthy balance: How endothelial AHR signaling helps regulate tissue homeostasis and protection

Cell Host Microbe. 2023 Oct 11;31(10):1593-1594. doi: 10.1016/j.chom.2023.09.008.

Authors

Rachel P Tat¹, Christopher M Robinson²

Affiliations

¹ Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
² Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: cmrobin@iu.edu.

PMID: 37827117
DOI: 10.1016/j.chom.2023.09.008

Abstract

Two recent Nature papers reveal that aryl hydrocarbon receptor (AHR) signaling in endothelial cells plays a vital role in cellular quiescence and tissue homeostasis. These studies highlight the important role endothelial cells of the vasculature system play in maintaining a healthy barrier that limits inflammation and protects against invading pathogens.

MeSH terms

Endothelial Cells* / metabolism
Homeostasis
Humans
Inflammation
Receptors, Aryl Hydrocarbon* / genetics
Receptors, Aryl Hydrocarbon* / metabolism
Signal Transduction

Substances

Receptors, Aryl Hydrocarbon

Grants and funding

R01 AI165611/AI/NIAID NIH HHS/United States