Accuracy of Apgar score and arterial cord-blood pH in diagnosis of perinatal brain-damage assessed by CK-BB isoenzyme measurement

J Perinat Med. 1986;14(5):335-8. doi: 10.1515/jpme.1986.14.5.335.


This study was carried out on 45 newborns to evaluate the accuracy of 1 minute Apgar score and umbilical arterial pH for prediction of the risk of perinatal brain damage. Using a new and very sensitive method for CK-BB determination, which is considered a good indicator of brain damage, CK-BB was used as reference. Patients with low Apgar score at one minute of life had significantly higher cord blood CK-BB values than the control group (p less than 0.01). No difference was found between the control group and the group with umbilical cord blood acidosis (p less than 0.2).

MeSH terms

  • Apgar Score*
  • Asphyxia Neonatorum / complications
  • Brain Damage, Chronic / diagnosis*
  • Brain Damage, Chronic / enzymology
  • Brain Damage, Chronic / etiology
  • Creatine Kinase / blood*
  • Fetal Blood* / enzymology
  • Humans
  • Hydrogen-Ion Concentration
  • Infant, Newborn
  • Isoenzymes
  • Prognosis


  • Isoenzymes
  • Creatine Kinase