The Genomic Signatures of Linitis Plastica Signal the Entrance into a New Era: Novel Approaches for Diagnosis and Treatment

Int J Mol Sci. 2023 Sep 28;24(19):14680. doi: 10.3390/ijms241914680.


Linitis Plastica (LP) is a rare and aggressive tumor with a distinctive development pattern, leading to the infiltration of the gastric wall, the thickening of the gastric folds and a "leather bottle appearance". LP is an extremely heterogeneous tumor caused by mutations in oncogenic and tumor suppressive genes, as well as molecular pathways, along with mutations in stromal cells and proteins related to tight junctions. Elucidating the molecular background of tumorigenesis and clarifying the correlation between cancerous cells and stromal cells are crucial steps toward discovering novel diagnostic methods, biomarkers and therapeutic targets/agents. Surgery plays a pivotal role in LP management, serving both as a palliative and curative procedure. In this comprehensive review, we aim to present all recent data on the molecular background of LP and the novel approaches to its management.

Keywords: Borrmann type IV; Linitis Plastica; biomarkers; oncogenes in LP; surgery; targeting agents.

Publication types

  • Review

MeSH terms

  • Genomics
  • Humans
  • Linitis Plastica* / diagnosis
  • Linitis Plastica* / genetics
  • Linitis Plastica* / therapy
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / genetics
  • Stomach Neoplasms* / therapy

Grants and funding

This research received no external funding.