Potential roles of the exosome/microRNA axis in breast cancer

Alireza Soleimani Mamalo; Vahid Alivirdiloo; Azadeh Sadeghnejad; Mobasher Hajiabbasi; Morad Kohandel Gargari; Mohammad Valilo

doi:10.1016/j.prp.2023.154845

Potential roles of the exosome/microRNA axis in breast cancer

Pathol Res Pract. 2023 Nov:251:154845. doi: 10.1016/j.prp.2023.154845. Epub 2023 Oct 5.

Authors

Alireza Soleimani Mamalo¹, Vahid Alivirdiloo², Azadeh Sadeghnejad³, Mobasher Hajiabbasi⁴, Morad Kohandel Gargari⁵, Mohammad Valilo⁶

Affiliations

¹ Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
² Medical Doctor Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran.
³ Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.
⁴ Medical Doctor, Islamic Azad University of Tonekabon, Tonekabon, Iran.
⁵ Imamreza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: valilo.biomed@gmail.com.

PMID: 37839359
DOI: 10.1016/j.prp.2023.154845

Abstract

Cancer is one of the most common diseases in the world, and various genetic and environmental factors play a key role in its development. Breast cancer is one of the most common and deadly cancers in women. Exosomes are extracellular vesicles (EVs) with an average size of about 100 nm that contain lipids, proteins, microRNAs (miRNAs), and genetic factors and play a significant role in cell signaling, communication, tumorigenesis, and drug resistance. miRNAs are RNAs with about 22 nucleotides, which are synthesized by RNA polymerase and are involved in regulating gene expression, as well as the prevention or progression of cancer. Many studies have indicated the connection between miRNAs and exosomes. According to their findings, it seems that circulating exosomal miRNAs have not been well evaluated as biomarkers for breast cancer diagnosis or monitoring. Therefore, given the importance of miRNAs in exosomes, the goal of the present study was to clarify the relationship between miRNAs in exosomes and the role they play as biomarkers in breast cancer.

Keywords: Breast Cancer; Chemotherapy; Exosome; Metastasis; MiRNA.

Publication types

Review

MeSH terms

Biomarkers / metabolism
Breast Neoplasms* / genetics
Breast Neoplasms* / metabolism
Circulating MicroRNA*
Exosomes* / genetics
Exosomes* / metabolism
Extracellular Vesicles* / metabolism
Female
Humans
MicroRNAs* / metabolism

Substances

MicroRNAs
Biomarkers
Circulating MicroRNA