The Influence of Dietary Counseling Over 20 Years on Tracking of Non-High-Density Lipoprotein Cholesterol from Infancy to Young Adulthood

Yaxing Meng; Harri Niinikoski; Suvi P Rovio; Brooklyn J Fraser; Feitong Wu; Antti Jula; Tapani Rönnemaa; Jorma S A Viikari; Olli T Raitakari; Katja Pahkala; Costan G Magnussen

doi:10.1016/j.jpeds.2023.113776

The Influence of Dietary Counseling Over 20 Years on Tracking of Non-High-Density Lipoprotein Cholesterol from Infancy to Young Adulthood

J Pediatr. 2024 Jan:264:113776. doi: 10.1016/j.jpeds.2023.113776. Epub 2023 Oct 14.

Authors

Affiliations

¹ Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, The University of Melbourne, Melbourne, Australia.
² Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, Turku, Finland.
³ Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
⁴ Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, Australia.
⁵ Department of Chronic Disease Prevention, Institute for Health and Welfare, Turku, Finland.
⁶ Division of Medicine, Turku University Hospital, Turku, Finland; Department of Medicine, University of Turku, Turku, Finland.
⁷ Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku, Finland.
⁸ Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Paavo Nurmi Centre, Unit of Health and Physical Activity, University of Turku, Turku, Finland.
⁹ Baker Heart and Diabetes Institute, Melbourne, Australia; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. Electronic address: Costan.Magnussen@baker.edu.au.

PMID: 37839509
DOI: 10.1016/j.jpeds.2023.113776

Abstract

This 26-year study found that non-high-density lipoprotein cholesterol (non-HDL-C) levels tracked from infancy to young adulthood suggesting early-life non-HDL-C could predict future levels. However, infancy-onset dietary counseling reduced the odds of maintaining at-risk non-HDL-C, highlighting the potential importance of early interventions in preventing cardiovascular risk associated with high pediatric non-HDL-C.

Keywords: adolescent; adult; child; cholesterol; controlled clinical trials; infant; randomized; trajectory.

MeSH terms

Adult
Child
Cholesterol*
Cholesterol, HDL
Counseling
Humans
Lipoproteins*
Risk Factors
Young Adult

Substances

lipoprotein cholesterol
Cholesterol
Lipoproteins
Cholesterol, HDL