LncRNA/CircRNA-miRNA-mRNA Axis in Atherosclerotic Inflammation: Research Progress

Nuan Lv; Yilin Zhang; Luming Wang; Yanrong Suo; Wenyun Zeng; Qun Yu; Bin Yu; Xijuan Jiang

doi:10.2174/0113892010267577231005102901

LncRNA/CircRNA-miRNA-mRNA Axis in Atherosclerotic Inflammation: Research Progress

Curr Pharm Biotechnol. 2023 Oct 12. doi: 10.2174/0113892010267577231005102901. Online ahead of print.

Authors

Nuan Lv¹, Yilin Zhang¹, Luming Wang¹, Yanrong Suo², Wenyun Zeng³, Qun Yu¹, Bin Yu⁴, Xijuan Jiang¹

Affiliations

¹ School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
² Traditional Chinese Medicine Department, Ganzhou People's Hospital, Ganzhou, China.
³ Oncology Department, Ganzhou People's Hospital, Ganzhou, China.
⁴ School of Medial Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

PMID: 37842894
DOI: 10.2174/0113892010267577231005102901

Abstract

Atherosclerosis is characterized by chronic inflammation of the arterial wall. However, the exact mechanism underlying atherosclerosis-related inflammation has not been fully elucidated. To gain insight into the mechanisms underlying the inflammatory process that leads to atherosclerosis, there is need to identify novel molecular markers. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-protein-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have gained prominence in recent years. LncRNAs/circRNAs act as competing endogenous RNAs (ceRNAs) that bind to miRNAs via microRNA response elements (MREs), thereby inhibiting the silencing of miRNA target mRNAs. Inflammatory mediators and inflammatory signaling pathways are closely regulated by ceRNA regulatory networks in atherosclerosis. In this review, we discuss the role of LncRNA/CircRNA-miRNA-mRNA axis in atherosclerotic inflammation and how it can be targeted for early clinical detection and treatment.

Keywords: Atherosclerosis; CircRNA; Inflammation; LncRNA; mRNA.; miRNA.