A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma?

Arthritis Rheum. 1979 Aug;22(8):904-10. doi: 10.1002/art.1780220815.


Six long term survivors of bone marrow transplants developed a syndrome similar to progressive systemic sclerosis (PSS). Cutaneous involvement (6/6), pulmonary disease (6/6), musculoskeletal involvement (4/6), keratoconjunctivitis/positive Schirmer's test (4/6), Raynaud's phenomenon (2/6), and renal and cardiac disease (1/6) were similar to findings in PSS patients. T and B lymphocyte counts and functions were also similar. This PSS-like syndrome, including visceral involvement, after bone marrow transplantation lends support to an immunologic hypothesis of the pathogenesis of progressive systemic sclerosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigen-Antibody Complex
  • B-Lymphocytes / immunology
  • Bone Marrow Transplantation*
  • Creatinine / urine
  • Graft vs Host Reaction
  • Humans
  • Scleroderma, Systemic / etiology*
  • T-Lymphocytes / immunology
  • Transplantation, Homologous / adverse effects*


  • Antigen-Antibody Complex
  • Creatinine