The impact of global warming on the signature virulence gene, thermolabile hemolysin, of Vibrio parahaemolyticus

Microbiol Spectr. 2023 Dec 12;11(6):e0150223. doi: 10.1128/spectrum.01502-23. Epub 2023 Oct 16.

Abstract

In this study, Vibrio parahaemolyticus strains were collected from a large number of aquatic products globally and found that temperature has an impact on the virulence of these bacteria. As global temperatures rise, mutations in a gene marker called thermolabile hemolysin (tlh) also increase. This suggests that environmental isolates adapt to the warming environment and become more pathogenic. The findings can help in developing tools to analyze and monitor these bacteria as well as assess any link between climate change and vibrio-associated diseases, which could be used for forecasting outbreaks associated with them.

Keywords: Vibrio parahaemolyticus; global warming; mutation rate; pathogenic potentials; thermolabile hemolysin (tlh); whole-genome sequencing.

MeSH terms

  • Global Warming
  • Hemolysin Proteins / genetics
  • Humans
  • Vibrio Infections* / microbiology
  • Vibrio parahaemolyticus* / genetics
  • Virulence / genetics

Substances

  • Hemolysin Proteins