Is creatine a CNS neurotransmitter?

Bhagaban Mallik; C Andrew Frank

doi:10.7554/eLife.91824

Is creatine a CNS neurotransmitter?

Elife. 2023 Oct 16:12:e91824. doi: 10.7554/eLife.91824.

Authors

Bhagaban Mallik¹, C Andrew Frank¹

Affiliation

¹ Department of Anatomy and Cell Biology, University of Iowa, Iowa City, United States.

Abstract

A range of experiments suggests that creatine, a molecule known for recycling ATP in muscle and brain tissue, may also function as a neurotransmitter in the central nervous system.

Keywords: AGAT; SLC6A8; astrocytes; creatine; inhibitory neurotransmission; mouse; neuroscience; synaptic vesicles.

Publication types

Editorial

MeSH terms

Brain
Central Nervous System*
Creatine*
Muscles

Substances

Creatine

Grants and funding

R01 NS130108/NS/NINDS NIH HHS/United States