Directing Uphill Strand Displacement with an Engineered Superhelicase

ACS Synth Biol. 2023 Nov 17;12(11):3424-3432. doi: 10.1021/acssynbio.3c00452. Epub 2023 Oct 16.

Abstract

The ability to finely tune reaction rates and binding energies between components has made DNA strand displacement circuits promising candidates to replicate the complex regulatory functions of biological reaction networks. However, these circuits often lack crucial properties, such as signal turnover and the ability to transiently respond to successive input signals that require the continuous input of chemical energy. Here, we introduce a method for providing such energy to strand displacement networks in a controlled fashion: an engineered DNA helicase, Rep-X, that transiently dehybridizes specific DNA complexes, enabling the strands in the complex to participate in downstream hybridization or strand displacement reactions. We demonstrate how this process can direct the formation of specific metastable structures by design and that this dehybridization process can be controlled by DNA strand displacement reactions that effectively protect and deprotect a double-stranded complex from unwinding by Rep-X. These findings can guide the design of active DNA strand displacement regulatory networks, in which sustained dynamical behavior is fueled by helicase-regulated unwinding.

Keywords: DNA nanotechnology; helicase; strand displacement reaction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA Helicases / genetics
  • DNA* / metabolism
  • DNA, Single-Stranded*
  • DNA-Binding Proteins / genetics
  • Nucleic Acid Hybridization

Substances

  • DNA, Single-Stranded
  • DNA
  • DNA Helicases
  • DNA-Binding Proteins