Neovascular Age-Related Macular Degeneration in a Predominantly Black Population

Ophthalmic Surg Lasers Imaging Retina. 2023 Oct;54(10):580-584. doi: 10.3928/23258160-20230927-01. Epub 2023 Oct 1.

Abstract

Background and objective: We intend to study the characteristics and outcomes of an understudied patient population with neovascular age-related macular degeneration (nAMD).

Patients and methods: This retrospective study evaluated presenting features and outcomes in a predominantly Black patient population with nAMD. A multivariate regression explored baseline characteristics predictive of 1-year vision.

Results: Sixty-three eyes were included. The median (interquartile range) baseline vision was 20/300 (20/80 to counting fingers). Patients' baseline optical coherence tomography findings showed a mean central subfield thickness of 336 µm; 80% (n = 35) and 41% (n = 18) had fluid and central scarring, respectively. The primary predictor for vision at year-one was baseline vision (P = 0.03, 95% CI: 0.04 to 0.91). All of those who gained ≥ 3 lines of vision lacked central scarring at baseline.

Conclusion: Further studies are needed to investigate how to improve earlier detection and treatment of nAMD in this patient population. [Ophthalmic Surg Lasers Imaging Retina 2023;54:580-584.].

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Cicatrix
  • Humans
  • Intravitreal Injections
  • Macular Degeneration* / diagnosis
  • Ranibizumab
  • Retina / pathology
  • Retrospective Studies
  • Tomography, Optical Coherence / methods
  • Visual Acuity
  • Wet Macular Degeneration* / diagnosis
  • Wet Macular Degeneration* / drug therapy

Substances

  • Angiogenesis Inhibitors
  • Ranibizumab