The interplay between α-Synuclein and NLRP3 inflammasome in Parkinson's disease

Biomed Pharmacother. 2023 Dec:168:115735. doi: 10.1016/j.biopha.2023.115735. Epub 2023 Oct 16.


α-Synuclein is a member of a protein of synucleins, which is a presynaptic neuron protein. It is usually highly expressed in the brain and participates in the formation and transmission of nerve synapses. It has been reported that abnormal aggregation of α-Syn can induce the activation of NLRP3 inflammasome in microglia, increase the production of IL-1β, and aggravate neuroinflammation. Therefore, it is recognized as one of the important factors leading to neuroinflammation in Parkinson's disease. In this paper, we aimed to explore the influence of post-translational modification of α-Syn on its pathological aggregation and summarize various pathways that activate NLRP3 triggered by α-Syn and targeted therapeutic strategies, which provided new insights for further exploring the origin and targeted therapy of Parkinson's disease.

Keywords: NLRP3; Neuroinflammation; Parkinson's disease; Pathophysiology; α-Synuclein.

Publication types

  • Review

MeSH terms

  • Humans
  • Inflammasomes / metabolism
  • Microglia / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Neuroinflammatory Diseases
  • Parkinson Disease* / metabolism
  • alpha-Synuclein* / metabolism


  • alpha-Synuclein
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • SNCA protein, human