Chronic alcohol consumption induces lipofuscin deposition in the rat hippocampus

Neurobiol Aging. Sep-Oct 1986;7(5):347-55. doi: 10.1016/0197-4580(86)90161-2.

Abstract

Previous investigations have suggested that chronic alcohol consumption accelerates a number of age-related changes in the cerebellar cortex and hippocampal formation. In the cerebellum, alcohol-feeding has been shown to accelerate the intracellular deposition of lipofuscin. In order to determine whether alcohol administration has a similar effect on hippocampal lipofuscin deposition, we studied the pattern of lipofuscin deposition in alcohol-fed rats for periods of 1, 3, 6, 12 and 18 months and compared the results with those obtained in the respective pair-fed controls. A precocious and progressive deposition of lipofuscin pigment was found in both CA1 and CA3 neurons in Ammon's horn hippocampal fields after 3 and 6 months of alcohol feeding, respectively. These results parallel those observed during normal aging and reinforce the hypothesis of a close link between chronic alcohol consumption and a premature nerve cell aging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Phosphatase / metabolism
  • Aging / pathology
  • Alcoholism / metabolism*
  • Alcoholism / pathology
  • Animals
  • Cytoplasmic Granules / metabolism
  • Hippocampus / metabolism*
  • Hippocampus / pathology
  • Lipofuscin / metabolism*
  • Male
  • Microscopy, Electron
  • Pigments, Biological / metabolism*
  • Rats
  • Rats, Inbred Strains

Substances

  • Lipofuscin
  • Pigments, Biological
  • Acid Phosphatase