Heritable Pulmonary Arterial Hypertension Diagnosed during the Postpartum Period: A Case Report and Literature Review

Turk Kardiyol Dern Ars. 2023 Oct;51(7):498-501. doi: 10.5543/tkda.2023.92263.


Approximately one-third of bone morphogenic protein receptor-2 (BMPR2) mutation carriers develop pulmonary arterial hypertension (PAH), which indicates that additional risk factors are needed for the manifestation of the disease. It is questionable whether pregnancy is a risk factor for PAH development in these patients. We represent a 30-year-old woman with a heterozygous BMPR2 mutation who was diagnosed with PAH during the postpartum period and reviewed the literature in this report. We also discussed the possible underlying mechanisms that might have resulted in PAH development during pregnancy in BMPR2 mutation carriers.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Adult
  • Bone Morphogenetic Protein Receptors, Type II / genetics
  • Bone Morphogenetic Protein Receptors, Type II / metabolism
  • Familial Primary Pulmonary Hypertension / diagnosis
  • Familial Primary Pulmonary Hypertension / genetics
  • Female
  • Humans
  • Hypertension, Pulmonary* / diagnosis
  • Hypertension, Pulmonary* / genetics
  • Mutation
  • Postpartum Period
  • Pregnancy
  • Pulmonary Arterial Hypertension*


  • Bone Morphogenetic Protein Receptors, Type II