A meta-analysis of gray matter volume abnormalities in HIV patients

Mingxiang Xu; Xing-Da Ju

doi:10.1016/j.pscychresns.2023.111722

A meta-analysis of gray matter volume abnormalities in HIV patients

Psychiatry Res Neuroimaging. 2023 Oct:335:111722. doi: 10.1016/j.pscychresns.2023.111722. Epub 2023 Oct 4.

Authors

Mingxiang Xu¹, Xing-Da Ju²

Affiliations

¹ School of Psychology, Northeast Normal University, No. 5268 Renmin Street, Changchun 130024, China.
² School of Psychology, Northeast Normal University, No. 5268 Renmin Street, Changchun 130024, China; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, Changchun,Jilin 130024, China. Electronic address: juxd513@nenu.edu.cn.

PMID: 37862957
DOI: 10.1016/j.pscychresns.2023.111722

Abstract

HIV infection is known to have significant effects on central nervous system. This study conducted a meta-analysis of whole voxel-based morphometry (VBM) in HIV patients (N = 435) and HIV-uninfected controls (N = 397). This study observed a reduction of limbic lobe, cingulate gyrus, frontal lobe, middle frontal gyrus, sub-lobar, insula, inferior frontal gyrus and superior frontal gyrus volume in HIV patients. These morphological differences may be responsible for cognitive decline in HIV patients, as these brain regions are closely related to motor and memory functions. These results contribute to a better understanding of the neural mechanisms underlying brain injury in HIV patients and could help develop targeted brain targets, provide more personalized treatment and predict neurodevelopmental outcomes.

Keywords: Brain development; Brain morphology; HIV; Neurocognitive impairment; VBM.

Publication types

Meta-Analysis
Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain / diagnostic imaging
Cerebral Cortex / diagnostic imaging
Gray Matter* / diagnostic imaging
HIV Infections* / complications
HIV Infections* / diagnostic imaging
Humans
Magnetic Resonance Imaging