Clinical significance of surface and internal pools of platelet-associated immunoglobulins in immune thrombocytopenia

Scand J Haematol. 1986 Sep;37(3):215-20. doi: 10.1111/j.1600-0609.1986.tb02300.x.


We have investigated serum platelet bindable IgG(SPBIgG) and platelet-associated IgG(PAIgG) in patients with immune thrombocytopenia (IT) to ascertain the significance of the larger amounts of PAIgG reported both in normals and in patients using homogenized (Total:T-PAIgG) instead of intact platelets (Surface:S-PAIgG). 12 patients, during active immune thrombocytopenia (A-IT), and 18 patients in steroid-induced remission (S-IT), were studied. As control we considered 20 patients with non-immune thrombocytopenia (N-IT) and 29 subjects with normal platelet count. The average positivity of SPBIgG was 41% with a higher percentage in A-IT (66%) than in S-IT (16%). The results of PAIgG also indicate a different behaviour in A-IT and S-IT of surface and cytoplasmatic pools. During A-IT both pools are enhanced with prevalence towards the surface one (S-PAIgG). On the contrary, during steroid-induced remission, despite the normal amount of the S-PAIgG present the internal pool still increases, indicating a steady-state of IT and the possible existence of a platelet phagocytic activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / immunology
  • Autoimmune Diseases / immunology*
  • Blood Platelets / immunology*
  • Child
  • Female
  • Humans
  • Immunoglobulin G / immunology*
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Middle Aged
  • Platelet Count
  • Purpura, Thrombocytopenic / immunology
  • Receptors, Antigen, B-Cell / immunology*
  • Thrombocytopenia / etiology
  • Thrombocytopenia / immunology*


  • Immunoglobulin G
  • Receptors, Antigen, B-Cell