Cardiovascular dysautonomia in postacute sequelae of SARS-CoV-2 infection

J Cardiovasc Electrophysiol. 2024 Mar;35(3):608-617. doi: 10.1111/jce.16117. Epub 2023 Oct 25.


Coronavirus disease 2019 (COVID-19) has led to a worldwide pandemic that continues to transform but will not go away. Cardiovascular dysautonomia in postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection has led to persistent symptoms in a large number of patients. Here, we define the condition and its associated symptoms as well as potential mechanisms responsible. We provide a careful and complete overview of the topic addressing novel studies and a generalized approach to the management of individuals with this complex and potentially debilitating problem. We also discuss future research directions and the important knowledge gaps to be addressed in ongoing and planned studies.

Keywords: COVID-19; autonomic nervous system; postacute COVID-29 syndrome; postural orthostatic tachycardia syndrome.

Publication types

  • Review

MeSH terms

  • Autonomic Nervous System Diseases*
  • COVID-19* / complications
  • Disease Progression
  • Humans
  • Pandemics
  • SARS-CoV-2